Drug Discovery in Preclinical Research (Track)
Preparation and Characterization of Ibuprofen Nanoparticles with Novel Technology: Solvent / Anti-solvent Precipitation
Mansouri Mansour
, Hamid Reza Pouretedal Department of Chemistry
Islamic azad university, Shahreza branch.
Malek-e-Ashtar University of Technology , Department of Chemistry, Shahin-Shahr, Isfahan , Iran.
Abstract:
Due to low aqueous solubility and slow dissolution rate, ibuprofen, a Non-steroidal anti-inflammatory drug (NSAID), has a low and variable oral bioavailability in water solution.A certain amount of drug was completely dissolved in water-miscible solvent (Isopropyl alcohol). The obtained drug solution was then injected into the anti-solvent, containing the (SDS / TEA) as stabilizer under stirring at 3000 rpm. Precipitation of solid drug particles occurred approximate 5 min during mixing.ForNon-steroidal anti-inflammatorydrugs (NSAID), like ibuprofen, we used the water as the anti-solvent. Ibuprofen nanoparticles exhibited significantly faster drug dissolution compared with raw drug. The dissolution rate of ibuprofen nanoparticles is 2.3times of raw drugs. This indicates that the acceleration of drug dissolution for nanoparticles occurs mostly in the first 30 min, after that, the dissolution has no significant difference from raw drugs. The accelerated dissolution for ibuprofen nanoparticles could thus be mainly ascribed to their greater surface area in comparison with raw drug. The precipitated ibuprofen nanoparticles had the same chemical structure with raw drug, but the particle size was reduced to 530.0 nm. Anti-solvent precipitation can thus be a simple and effective approach to produce submicron particles of poor water soluble drugs.
